PDF BookPhysiology and Pathology of Chloride Transporters and Channels in the Nervous System From Molecules to Diseases

Free PDF Physiology and Pathology of Chloride Transporters and Channels in the Nervous System From Molecules to Diseases

Free PDF Physiology and Pathology of Chloride Transporters and Channels in the Nervous System From Molecules to Diseases

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The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 yearsChloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume controlThe first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammationSpanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseasesInvolves all of the leading researchers in the fieldIncludes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field Resolve a DOI Name Type or paste a DOI name into the text box. Click Go. Your browser will take you to a Web page (URL) associated with that DOI name. Send questions or comments to doi ... Human Physiology/Print Version - Wikibooks open books for ... Homeostasis Overview. The human organism consists of trillions of cells all working together for the maintenance of the entire organism. While cells may perform very ... Osteopetrosis NEJM This review of the mechanism of osteopetrosis incriminates molecular defects in osteoclasts as the cause of the imbalance between bone formation by osteoblasts and ... Kidney - Wikipedia Details; System: Urinary system and endocrine system: Artery: Renal artery: Vein: Renal vein: Nerve: Renal plexus: Identifiers; Latin: Ren: Greek: Nephros: MeSH: A05 ... Adult Hypothyroidism - Thyroid Disease ManagerThyroid ... 9.3 CAUSES OF HYPOTHYROIDISM. A variety of functional or structural disorders may lead to hypothyroidism the severity of which depends on the degree and duration of ... Gramicidin - Wikipedia Gramicidin is a heterogeneous mixture of three antibiotic compounds gramicidins A B and C making up 80% 6% and 14% respectively all of which are obtained from ... The Enteric Nervous System NEJM The enteric nervous system is a collection of neurons in the gastrointestinal tract1 that constitutes the brain of the gut and can function independently of the ... Immunostar - Tyrosine Hydroxylase Antibody The tyrosine hydroxylase antibody was successfully used for immunostaining of dopamine neurons in the adult Drosophila brain. The antibody performed very well for ... Physiology of adult Homo sapiens - Nervous system Nervous system (neurology): the organ system which along with the endocrine system correlates the adjustments and reactions of an organism to internal and ... HISTOLOGY FULL-TEXT West Virginia University Chapter 1 HISTOLOGY: METHOD AND MICROSCOPY A NATURE OF HISTOLOGY Medical histology applies microscopy to the human body seeking to discover the nature of its smaller ...
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